Palmitoyl-KVK-L-ascorbic acid conjugate improves matrix abnormality associated with skin aging via epigenetic regulation
Journal of Dermatological Science（2021）
Abstract
•DNA methyltransferase 1 (DNMT1) is implicated in epigenetic skin aging.•DVP modulated DNMT1 and extracellular matrix in vitro and in vivo.•Skin anti-aging epigenetic mechanism of DVP was revealed.•Potential of DNMT1 inhibitors as skin anti-aging agents was validated.
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Key words
DNMT,UV,DVP
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