Sticholysins, pore-forming proteins from a marine anemone can induce maturation of dendritic cells through a TLR4 dependent-pathway

•TLR4/MyD88 pathway is relevant for Sts-induced dendritic cells maturation.•The 3D-structure of Sts is important for inducing dendritic cells maturation.•Free Sts mediate Ag cross-presentation in dendritic cells with CD8+ T cell priming.•TLR4 is involved in the CD8+ T cell response induced by StII-carrying liposomes.