Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation

Marco Salamina,Bailey C Montefiore,Mengxi Liu,Daniel J Wood,Richard Heath,James R Ault,Lan-Zhen Wang,Svitlana Korolchuk,Arnaud Baslé,Martyna W Pastok,Judith Reeks,Natalie J Tatum,Frank Sobott,Stefan T Arold,Michele Pagano,Martin E M Noble,Jane A Endicott

Journal of Molecular Biology（2021）

引用 8|浏览37

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摘要

•SKP2 engages a site on the N-terminal lobe of cyclin A.•SKP2 recruits a catalytic CDK2-cyclin A to CDK2-cyclin A-CKS1-p27KIP1-SKP1-SKP2.•The SKP2 and p27KIP1 binding sites on cyclin A are divergent but overlap.•SKP2 engages with CDK2-cyclin A by two distinct structural mechanisms.

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关键词

cell cycle,checkpoint,protein kinase,signaling,ubiquitination

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