Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated And Associated With Poor Prognosis In Acute Myeloid Leukemia

Background. Monocytic myeloid-derived suppressor cells (M-MDSCs) characterized with the phenotype of CD14(+)HLA-DRlow/- have attracted a lot of attention in the field of human tumor immunology. However, little is known about the roles of M-MDSCs in acute myeloid leukemia (AML) as opposed to their multiple roles in solid tumors. Methods. We examined the frequencies of M-MDSCs identified for CD14(+)HLA-DRlow/- by flow cytometry in the peripheral circulating blood of 109 newly diagnosed adult patients with AML and 30 healthy controls (HC). Then, we, respectively, validated the clinic significance of circulating M-MDSCs on the relevance of spectral features for diagnostic stratification, induction therapy response, treatment effect maintenance, and long-term survival in AML. Results. Circulating M-MDSC frequencies of AML were significantly higher than those of HC both in CD14(+) monocytes (46.22%+/- 2.95% vs. 1.07%+/- 0.17%, p<0.01) and peripheral blood mononuclear cells (PBMCs) (4.21%+/- 0.80% vs. 0.17%+/- 0.03%, p<0.01). Elevated circulating M-MDSCs in patients with AML were significantly associated with low complete remission (CR) rate, high relapse/refractory rate, and poor long-term survival, but had no correlation with common clinic risks and cytogenetic molecular risk categories. Conclusions. It was demonstrated that circulating M-MDSCs are elevated and associated with poor prognosis in AML, suggesting M-MDSCs might be a prognostic indicator for AML.