Epigenetic Memories: The Hidden Drivers Of Bacterial Persistence?
TRENDS IN MICROBIOLOGY(2021)
摘要
Epigenetic modifications, including DNA methylation, stably alter gene expression without modifying genomic sequences. Recent evidence suggests that epigenetic regulation coupled with a long-term 'memory' effect plays a major role within bacterial persistence formation. Today, emerging high-resolution, single molecule sequencing technologies allow an increased focus on DNA modifications as regulatory epigenetic marks, which presents a unique opportunity to identify possible epigenetic drivers of bacterial persistence.
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关键词
DNA methylation,SMRT sequencing,bacterial persistence,epigenetic inheritance,gene expression regulation,nanopore sequencing
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