Alpha-asarone Improves Cognitive Function of APP/PS1 Mice and Reducing Aβ42, P-tau and Neuroinflammation, and Promoting Neuron Survival in the Hippocampus

Lili Zeng,Di Zhang,Qi Liu,Jian Zhang,Keman Mu,Xiaofeng Gao,Kun Zhang,Hui Li,Qiantao Wang,Yongxiang Zheng,Shengjun Mao

Neuroscience（2021）

引用 13|浏览12

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摘要

•Alpha-asarone improves the cognitive function of APP/PS1 transgenic mice.•Alpha-asarone reduced Aβ42 and p-tau protein levels in the hippocampus.•Alpha-asarone reduced the brain GFAP expression and alleviated neuroinflammation.•Alpha-asarone decreased autophagosomes and promoted hippocampal neuron survival.•Alpha-asarone might be a promising drug candidate for the treatment of AD.

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关键词

AD,GABA,Aβ,p-tau,GAD,GFAP,CNS,NFTs,GABAA-R,WT,MWM,OFT,SDL,ET,H&E,ELISA,TNF-α,IL-1β,IL-6,TEM,ANOVA

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