Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma.

Soichiro Nishioka,Ping-Hsiu Wu, Toshiaki Yakabe,Amato J Giaccia,Quynh-Thu Le,Hidefumi Aoyama,Shinichi Shimizu,Hiroki Shirato,Yasuhito Onodera,Jin-Min Nam

Neuro-oncology advances（2020）

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摘要

Our results show that Rab27b mediates the radioresistance of highly malignant GBM cells. Rab27b promotes the proliferation of adjacent cells through EREG-mediated paracrine signaling after irradiation. Thus, the Rab27b-EREG pathway is a novel potential target to improve the efficacy of radiotherapy in GBM.

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关键词

Rab27b,epiregulin,glioblastoma,paracrine,radioresistance

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