B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased

Jana Ihlow, Edward Michaelis,Selina Greuel,Verena Heynol,Annika Lehmann,Helena Radbruch,Jenny Meinhardt,Florian Miller,Hermann Herbst,Victor Max Corman,Jörg Westermann,Lars Bullinger,David Horst,Ann-Christin von Brünneck,Sefer Elezkurtaj

International Journal of Infectious Diseases（2021）

引用 15|浏览20

暂无评分

摘要

•Lymphocytopenia in COVID-19 decedents is accompanied by B cell depletion in bone marrow and spleen.•COVID-19 decedents with B cell loss show a tendency towards higher pulmonary SARS-CoV-2 burden.•Loss of B cells and plasma cells may impede the humoral immune response to SARS-CoV-2.•COVID-19 decedents show signs of sepsis-induced immunodeficiency in the bone marrow.

查看译文

关键词

COVID-19,SARS-CoV-2,Bone marrow,Spleen,B cells,Sepsis,Immunodeficiency,Humoral immune response

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要