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Accelerated Development of a Scalable Ring-Closing Metathesis to Manufacture AMG 176 Using a Combined High-Throughput Experimentation and Computational Modeling Approach

Gabrielle St-Pierre,Alan H. Cherney, Wencan Chen,Xiaofei Dong,Peter K. Dornan,Daniel J. Griffin,K. N. Houk, Janice B. Lin,Stephen Osgood,Maria V. Silva Elipe, Heath C. Timmons,Yong Xie,Jason S. Tedrow,Oliver R. Thiel,Austin G. Smith

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2021）

Cited 14|Views28
Key words
AMG 176,ring-closing metathesis,high-throughput experimentation,process development,pharmaceutical manufacture,process design
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