Inhibition Of Egfr Signalling Promotes Maladaptive Cardiac Remodelling In Hypertensive Heart Disease

Susanna Cooper,Zoe Haines, Viridiana Alcantara Alonso,Joshua J. Cull,Feroz Ahmad,Hajed O. Alharbi,Stephen Fuller,Peter Sugden,Angela Clerk,Daniel N. Meijles

Circulation（2020）

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摘要

Introduction: Epidermal growth factor (EGF) receptors (EGFRs: ERBB1-4) are activated by a family of ligands (e.g. EGF, Hb-EGF, EREG, TGFa), signaling through ERK1/2 and Akt to promote cell division...

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egfr signalling promotes,hypertensive heart disease,maladaptive cardiac remodelling

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