Selective Platelet Protease-Activated-Receptor (Par)1 And Par4 Mediated Thrombin Desensitisation In The Elderly Is Correlated With Inflammation And Chronic Thrombin Receptor Stimulation

Sonali R. Gnanenthiran,Gabrielle Pennings,Caroline Reddel,Heather Campbell,Justin Hamilton,Vivien Chen,Leonard Kritharides

Circulation（2020）

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摘要

Introduction: Platelet activation, by adenosine diphosphate (ADP) via P2Y12 receptors and thrombin via PAR1 and PAR4, is a key therapeutic target in cardiovascular disease (CVD). The efficacy of an...

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par4 mediated thrombin desensitisation,platelet,inflammation,protease-activated-receptor

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