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Dose-Related Reductions In Blood Pressure With A Rna Interference (Rnai) Therapeutic Targeting Angiotensinogen In Hypertensive Patients: Interim Results From A First-In-Human Phase 1 Study Of Aln-Agt01

Stephen A. Huang,Jorg Taubel, Giuseppe Fiore, Peter Dewland,George L. Bakris,Akshay S. Desai,Yansong Cheng,Sagar Agarwal,Jamie Harrop,Huy V. Nguyen,Jiandong Lu,Don Foster,Akshay Vaishnaw,Jae B. Kim

Circulation（2020）

Cited 16|Views4
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Abstract
Background: Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides and plays a key role in hypertension pathogenesis. We evaluated the effect of ALN-AGT01, a subcutaneous investiga...
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Key words
therapeutic targeting angiotensinogen,hypertensive patients,rna interference,blood pressure,rnai,dose-related,first-in-human,aln-agt
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