Local Aldosterone Production Via Star In Pah And In Human Ips Cell-Derived Cardiomyocytes: Efficacy Of Spironolactone In Cardiac Remodeling And Mitochondrial Dynamics Under Hypoxic Stress

Itsumi Murai,Anyu Kaiami,Ryuji Kato,Hideki Imano,Hirofumi Morihara,Kiichiro Tomoda,Michio Asahi,Yoshio Ijiri,Takehiro Yamaguchi,Yasukatsu Izumi,Minoru Yoshiyama,Keiko Ohta-Ogo,Hatsue Ishibashi-Ueda,Tetsuya Hayashi

Circulation（2020）

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摘要

Objective: Pulmonary arterial hypertension (PAH) is a progressive disease that frequently leads to right ventricular (RV) remodeling. Increased plasma aldosterone levels have been reported in patie...

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