T-Cell Immune Surveillance In Allogenic Stem Cell Transplant Recipients: Are Whole Blood-Based Assays Ready To Challenge Elispot?

Chris D Lauruschkat,Lukas Page,Sonja Etter,Philipp Weis,Florian Gamon,Sabrina Kraus,Hermann Einsele,Sebastian Wurster,Juergen Loeffler

OPEN FORUM INFECTIOUS DISEASES（2021）

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摘要

We compared the feasibility of 4 cytomegalovirus (CMV)and Aspergillus-reactive T-cell immunoassay protocols in allogenic stem cell transplant recipients. While enzyme-linked immunospot performed best overall, logistically advantageous whole blood-based assays performed comparably in patients with less severe lymphocytopenia. CMV-induced interferon-gamma responses correlated strongly across all protocols and showed high concordance with serology.

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关键词

immunoassay, biomarker, aspergillosis, cytomegalovirus, T cells, cytokines, flow cytometry, ELISPOT

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