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Resolving A Controversy: Inhibition Of Cardiac Ryanodine Receptors Is The Principal Mechanism Of Antiarrhythmic Action Of Flecainide In Catecholaminergic Polymorphic Ventricular Tachycardia

Dmytro O. Kryshtal,Daniel J. Blackwell,Christian L. Egly,Abigail N. Smith,Suzanne M. Batiste,Jeffrey N. Johnston,Derek R. Laver,Bjorn C. Knollmann

Circulation（2020）

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Abstract
Rationale: The class Ic antiarrhythmic drug flecainide prevents ventricular tachyarrhythmia in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a disease caused by hypera...
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Key words
cardiac ryanodine receptors,antiarrhythmic action,flecainide
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