The Diverse Roles Of T Cell Subsets In Asthma

T cells are coordinators of the immune response and have been shown to play a central role in the pathophysiology of asthma. A good understanding of the T cells functions in asthma is important for therapeutic reasons, in particular for the choice of biological treatments in severe asthma. Although classically considered a Th2 disease, it is now clear that other types of T cells contribute for the pathophysiology and the heterogeneity of asthma. We here review how the different subsets of T cells are involved in the different phenotypes/endotypes of asthma and how this may influence the treatment of the disease.Impact statementThis review highlights the heterogenity of ashtma and the significant role of other types of T-cells aside from Th2 (including unconventional subsets) in its development and symptoms.