Synthesis of Pyrrolo[2,3]pyrido[2,4-d]pyrimidin-6-ones and Related New Heterocycles
Heterocycles(2020)
摘要
During our synthetic development work focused on new Bcl-2 inhibitor molecules an unexpected and interesting by-product was formed. Using this obsevation we have explored the synthesis of the hitherto unknown pyrrolo[2,3]pyrido[2,4-d]pyrimidin-6-one heterocyclic core. The study of the scope and limitations of this cyclisation resulted in other three new types of three membered heterocyclic ring systems.
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