Multiplatform Profiling Characterizes Functional Networks In Genomically Stable And Instable Chronic Lymphocytic Leukemia

Background: Genomically instable (GI) chronic lymphocytic leukemia (CLL) is characterized by frequent alterations in DNA-damage response (DDR) genes (e.g. TP53, ATM) and related pathways. Conversely, pathogenic networks in CLL cases which maintain genomic integrity and operate with a functional DDR remain incompletely described.