Targeted exhaled breath analysis for detection of Pseudomonas aeruginosa in cystic fibrosis patients

•Extensive literature review of compounds associated with Pseudomonas aeruginosa.•A hypothesis driven targeted approach as novel way of validating volatile organic compounds as biomarkers.•Paediatric and adult populations require separate analyse; they express different breath profiles.•Biomarkers from exhaled breath can yield high sensitivity for bacterial infection in cystic fibrosis patients.