Association Between Sleep Hours And Cardiovascular-Cerebrovascular Morbidity, Mortality And Cancer

Objective: Describe sleep habits of a general population of men and evaluate the association between sleep hours and morbidity- mortality associated after a 20 years of follow-up. Methods: Prospective study in which 1050 men, 30-70 years from Vitoria-Gasteiz were included, and 20 years followed. Clinical data were collected and a respiratory polygraphy was performed at the beginning and the end. We analyzed mortality, the "composite" (cardiovascular and cerebrovascular disease) and cancer diagnosis using the Kaplan-Meier method and Cox regression. Data are expressed in median (interquartile range), media (SD) or frequency. Data on sleep habits in 958 subjects at baseline [median age 48.0 (17.0), BMI 25.9 (4.0)] and in 449 subjects after a median of 271 (9.0) months [median age 67.6 (12.7), BMI 27.5 (4.0)]. The distribution of subjects according to the hours of sleep (<6, 6-7.9,> 8h) are specified in Table 1. There were no significant differences regarding baseline comorbidity between the 3 groups (p = 0.290). Despite observing a higher mortality in groups with <6 hours and > 8 hours of sleep compared to those of 6-8 hours (Log Rank; p = 0.002), after the adjustment for the different independent variables in Cox regression models, sleeping <6 hours and > 8 hours was not associated with a higher mortality (p = 0.608), cardiovascular consequences (p = 0.433) neither cancer diagnosis (p = 0.787 ).There was not significant differences in the "composite" of any adverse morbidity-mortality event (p = 0.794) or by age groups. Conclusion: Restriction or increase of sleep hours are not significantly associated with mortality or cardiovascular comorbidity or cancer in a general population of men.