Isolation of ovarian cancer circulating tumor cells using an epitope independent microfluidic cell capture device and their interrogation using a multiplex gene expression assay or immunofluorescence

Objective: The current study was designed to evaluate the ability of an epitope independent microfluidic cell capture device to isolate circulating tumor cells (CTCs) from the blood of women with stage III–IV high-grade serous ovarian cancer (HGSOC) that could subsequently be evaluated using either a highly multiplexed gene expression assay or by immunofluorescence (IF).