The Relationship Analysis Of Microrna-146a Rs2910164 Polymorphism With Risk Of Colorectal Cancer In Province Of South-Khorasan, Iran

Introduction: Colorectal cancer (CRC) is a health obstacle and one of the most prevalent reasons of neoplasm linked death among of the different nations. The researches have revealed that occurrence of this neoplasm is influenced by environmental and genetic risk factors. Recently, it is reported the association of rs291016 polymorphism in microRNA-146a (miR-146a) gene with risk of different neoplasms such as CRC. In existent study, we have investigated role of this polymorphism in CRC risk for the first time in the province of South Khorasan, east of Iran.Materials and method: In this research, the 54 people with CRC and 116 healthy people are selected from this province. After collecting blood samples and extracting genomic DNAs, the genotyping is conducted by PCRRFLP technique. Finally, the data is analyzed using the SPSS program (16 version).Results: After the data analysis and computing of odds ratio (OR) and P-value, it is detected the statistically important connections in comparison between rs291016 GG genotype and CC genotype (OR = 1.594, 95% CI = 1.380-1.841, P < 0.001), GG genotype versus CC + CG genotypes (OR = 1.681, 95% CI = 1.447-1.954, P < 0.001), G-wild allele compared to C-mutant allele (OR = 1.296, 95% CI = 1.208-1.390, P < 0.001) among case and control groups.Conclusion: The miR-146a rs2910164 GG genotype and G allele can be suggested as risk factors for occurrence of CRC in the studied patients.