Physical Training Improves Lung Function And Mechanics And Pulmonary And Systemic Immune Response In Eutrophic Women

Although physical training can classically improve lung function and systemic immune response, no information is available about the effects of combined aerobic and resistance training on lung mechanics and pulmonary immune response. Thus, 12 eutrophic women (41.56±5.98 years old, BMI 21.94±4.49 kg/m2) were submitted to 12 weeks, 3x/week, 50min/session of aerobic (20min; 75% Max. HR) + resistance (30min; 75% 1MR) training. The results demonstrated that 12 weeks of combined training did not alter the lung function measured by spirometry, but improved the lung impedance (p<0.005), total resistance of respiratory system (p<0.0001), resistance of proximal airways (p<0.0001), resistance of distal airways (p<0.003), lung capacitance (p<0.007), central tissue resistance (p<0.01), peripheral tissue resistance (p<0.02). In addition, combined training increased the levels of pulmonary anti-inflammatory mediators adiponectin (p<0.04) and IL-10 (p<0.01), and reduced the levels of pro-inflammatory IL-1beta (p<0.02), measured in the breath condensate. Systemically, combined training increased the levels of serum anti-inflammatory mediator adiponectin (p<0.001), IL-10 (p<0.01), IL-1ra (p<0.03) and klotho (p<0.002), while decreased the levels of pro-inflammatory mediator IL-1beta (p<0.0001) We conclude that combined training was useful to improve lung mechanics and lung and systemic immune response in eutrophic women.