COVID-19 in a Down Syndrome Newborn

A 36-week premature newborn with trisomy 21, had a fever, runny nose and mild dyspnea at 27 days old. Parents had flu-like symptoms. He was admitted to intensive care unit (ICU), in isolation with support therapy. His reverse transcription-polymerase chain reaction (RT-PCR) test for coronavirus disease 2019 (COVID-19) was positive. He had leukopenia and lymphopenia and increased C-reactive protein (CRP) levels, associated with mixed and interstitial opacities on chest radiography. Antibiotic therapy was performed with ampicillin and gentamicin for 10 days. He had improvement of symptoms, with worsening of CRP levels. On the 11th day of hospitalization antibiotic therapy was replaced by clarithromycin, which was performed for 5 days, with laboratory improvement after introduction. Chest computed tomography (CT) showed bilateral ground-glass lesions. He had a good recovery and was discharged from hospital with 17 days of hospitalization. Int J Clin Pediatr. 2020;9(4):116-119 doi: https://doi.org/10.14740/ijcp396