Impact Of Axial Ligation On Photophysical And Photodynamic Antimicrobial Properties Of Indium (Iii) Methylsulfanylphenyl Porphyrin Complexes Linked To Silver-Capped Copper Ferrite Magnetic Nanoparticles
POLYHEDRON(2021)
摘要
Photodynamic antimicrobial chemotherapy (PACT) is a well-known technique used against bacteria that have developed resistance towards antibiotics. We herein report the synthesis, photophysical properties, and PACT activity of 2-hydroxypyridine axial ligated indium 5,10,15,20-tetrakis-(4-phenylmethylthio) porphyrin (3) and quaternized 2-hydroxypyridine axial ligated indium 5,10,15,20-tetrakis-(4-phenylmethylthio) porphyrin (4). The porphyrin complexes (3 and 4) were further linked to oleyamine (OLM)/oleic acid (OLA) capped Ag/CuFe2O4 and also 6-mercapto-1-hexanol functionalized (MCH-Ag/CuFe2O4) nanoparticles through silver sulphur (Ag-S) and silver-nitrogen (Ag-N); self-assembly. The PACT studies were carried out using Staphylococcus aureus. While all the synthesized porphyrins demonstrated PACT activity, the quaternized complex and its conjugate showed the highest PACT activity with 0% cell viability after irradiation for 25 min, resulting in a log reduction of 8.31. (C) 2020 Elsevier Ltd. All rights reserved.
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关键词
Porphyrins, Magnetic nanoparticles, Photodynamic antimicrobial chemotherapy, Photosensitizer, Staphylococcus aureus
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