Identification of the lead compounds for the treatment of breast cancer using phytochemicals: A bioinformatics approach

Among all the type of cancer, the incidence of breast cancer has been increasing despite the fact that the efforts to prevent the disease has been improving. The traditional chemotherapy has been shown to be effective though it exhibit some serious adverse effects as the targets of the chemotherapeutic agents are nonspecific in most cases. Hence the chemotherapeutic agents affects the normal cells leading to the adverse effects. However researchers have been working for the past two decades to find the alternative treatment to the cancer with lesser adverse effect. Natural products or the bioactive compounds from natural sources have been proved to be less toxic. Fucoidan is one such natural polysaccharide of sulphated fucose residues from seaweed. Fucoidan have been used in cancer treatment in many countries. In this study we analyse the ability of fucoidan to treat breast cancer using in silico approaches.