Studying the Synergistic Effect of both Propolis Extract and Green Apple Peel Extract with Fluconazole against Candida albicans

Candida albicans were isolated from 36 isolates of the mouth people aged (2.5 – 63) years. A crude sample of bees propolis was collected from several apiaries in Mosul city and green apples were collected from the markets, evaluating antifungal of fluconazole, methanol extract of propolis (MPE) and methanol extract of green apples peels (MEGAP) were different concentration (125,250,375,500,750,1000,1500)ug/ml, each one alone and as combination of (fluconazole 50%+ MPE 50%) and of (fluconazole 50%+ MEGAP50%). Each one alone, the fluconazole only had inhibitory effect against C.albicans. As combination, the synergistic effect was observed of both combination (fluconazole 50% + EMP 50%) and (fluconazole 50%+MEGAP 50%) against C.albicans. In comparing between two combination observed that it was outdoing in a synergistic effect of (EMP) compared with (EMGAP) specially at concentrations (750 , 1000, 1500) ug/ml.