Comparative Study of the Dose-Dependent Effects of the Osmoregulators Sorbitol and Mannitol in Asaparkam-L on Diuresis and Saluresis in Rats

The effects of the osmoregulators D-sorbitol and D-mannitol in Asparkam-L solution for infusion on diuresis and urinary K + and Mg 2+ excretion were studied in white mongrel rats. Animals received single i.v. doses of samples of the formulation Asparkam-L: 1) with osmoregulator D-sorbitol; 2) with osmoregulator D-mannitol, 3) without osmoregulator, at the recommended one-time dose (1ROTD, calculated from the dose of 10 ml for a human with the average body weight of 70 kg) and at doses 2, 4, and 6 times greater than 1ROTD. Use of all study doses produced a background of minor oscillations in diuresis, with the smallest levels of urinary K + and Mg 2+ excretion with sample 1 and the largest with sample 2. Levels of K + and Mg 2+ excretion in rats given sample 2 were statistically significantly greater than those in control animals given 0.89% NaCl at a volume equivalent to that of 6 ROTD. Increased K + and Mg 2+ excretion after use of sample 2 probably indicated lower efficacy and the inadvisability of using mannitol as osmoregulator in the formulation intended to make up for deficit of these cations.