Secoiridoid glycosides from the fruits of Cornus officinalis

Five new secoiridoid glycosides, cornusphenosides E-I (1–5), were isolated and characterized from an active fraction of ethanol extract of the fruits of Cornus officinalis. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound 5 (when evaluated at 10 μM) showed the neuroprotective effect against H2O2-induced SH-SY5Y cell damage.