Synthesis of 1-[3-(hetaryl)allyl]morpholines As Potential Anticholinesterase Agents
Russian journal of general chemistry(2020)
摘要
A number of new pyrazole and pyrimidine derivatives containing an allylmorpholine fragment were obtained by reactions of chromone-containing allylmorpholines with 1,2- and 1,3-binucleophiles (hydrazine, guanidine, acetamidine). The syntheses were carried out under mild conditions (ethanol, room temperature), and the target products were isolated with high yields. The obtained compounds are of interest as potential cholinesterase inhibitors.
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关键词
chromone,allylamine,morpholine,pyrazole,pyrimidine,anticholinesterase activity
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