Incidence Of Coinfection In Patients With Covid-19

SESSION TITLE: Chest Infections Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: A recent surge of novel COVID-19 has diverted the focus from other microbial organisms as the etiology of respiratory illness. Causal agents for respiratory infections have been linked to different risk factors and clinical presentations. The propose of this study is to analyze the incidence of coinfection and the factors that determine it. METHODS: Respiratory Pathogen Panel (RPP), targeting 21 different organisms, was performed to randomized individuals undergoing testing for COVID-19 RT-PCR at four testing locations in Houston, Texas between March 2020 to May 2020. Tested subjects were inquired about their demographic information, positive exposure to COVID-19, current symptoms, and comorbidities. RESULTS: A total of 10,853 RPP tests were performed alongside COVID-19 RT-PCR (43,443) tests completed across the 4 locations. 4,195 (9.6%) patients had positive results for COVID-19. The total positive results for RPP was 1,276 (11%). Both RT-PCR and RPP were positive in 78 cases (0.7%), with 12 different organisms identified as the causal agents in these cases. The most common being Rhinovirus in 37.1% (n=29), followed by Staphylococcus Aureus in 33.3% (n=26) and Haemophilus influenzae 21.7%, (n=17). Other organisms included S. pneumonia, K. pneumonia, Influenza A, Influenza B, parainfluenza virus, metapneumovirus, adenovirus, enterovirus, and other strains of coronavirus. 7 cases were identified to have 2 positive organisms in RPP, in addition to being positive to COVID-19. 5 of which included rhinovirus and 4 of them had H. influenzae. Age was found to have a great influence on the incidence of different organisms of these concomitant infections. From the 11 cases that were 18 years old or younger, 45.4% had S. aureus as the causal agent and 27.2% were positive for H. influenzae. Cases among individuals >65 years old were positive only for rhinovirus. CONCLUSIONS: A positive test for respiratory pathogens does not exclude the coinfection with COVID-19 or vice versa. Age seemed to be the factor with the highest influence in determining the causal agent of these concomitant infections. CLINICAL IMPLICATIONS: Workup for respiratory infections should include testing for COVID-19, given that a positive RPP in a symptomatic or asymptomatic patient does not exclude concomitant infection with the novel coronavirus. Age range should also be considered as a determinant factor influencing causal agent of coinfection. DISCLOSURES: No relevant relationships by Frida Andrea Alvarez Velazquez, source=Web Response No relevant relationships by Valeria Demeneghi Aleman, source=Web Response No relevant relationships by JOSE ALFONSO GARNETT CARBAJAL, source=Web Response No relevant relationships by Mariya Mohiuddin, source=Web Response No relevant relationships by Salim Surani, source=Web Response No relevant relationships by Daryelle Varon, source=Web Response No relevant relationships by Joseph Varon, source=Web Response