A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells
RSC ADVANCES(2020)
摘要
Peroxynitrite (ONOO-) is a potent biological oxidant that plays a significant role in diverse physiological and pathological processes. A novel fluorescent probe HCA-OH was developed for specific and sensitive detection of peroxynitrite, and displayed a significant fluorescence turn-on signal. With low cytotoxicity and good photostability, the probe HCA-OH could be applied in imaging ONOO- distribution in HepG2 cells and live C. elegans in real time. Therefore, the probe can be a promising tool for imaging in vivo.
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关键词
peroxynitrite detection,fluorescence probe,cells,imaging,naphthalimide-based
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