Non-Brca Hereditary Gene Mutations In The Mongol Breast Cancer Patients Of Russia

Background: Breast cancer (BC) is the most prevalent female malignancy worldwide. In Russians, who were descended primarily from Slavic ancestors (newcomers), a strong founder effect was observed for the BRCA1 5382insC allele, which account up to 90% of all known BC-associated mutations in this population. To date, despite a significant burden of cancer and limited access to genetic cancer risk assessments there are a limited number of reports on the inherited gene mutations associated with BC among ethnic groups in Russia. The present study aimed at identifying mutations of BC-associated genes in 73 unrelated ethnically diverse BC patients (Mongoloid race) of Russia.