Factors Affecting Locoregional Recurrence Rate Of Breast Conserving Surgery In Patients With Neoadjuvant Chemotherapy

Background: Breast conserving surgery(BCS) is preferred over traditional mastectomy for better cosmetic and non-inferior oncological outcome. BCS is best indicated for early stage breast cancer with relatively small tumor size. Neo-adjuvant chemotherapy(NAC) helps downstaging locally advanced breast cancer and increase the possibility for BCS. However, recent meta-analysis from the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) showed a higher locoregional recurrence(LLR) rate in the NAC group than in the adjuvant chemotherapy group. Thus, the aim of this study was to retrospectively explore the factors affecting the LRR rate in breast cancer patients receiving BCS after NAC.