Risk Factors Associated With Recurrence Within 90 Days Of Ischemic Stroke Onset In Chinese Medicine Hospital: A National Cross-Sectional Study In China

Objective: The short- and long-term risk factors for stroke recurrence may be different. This study is aimed to determine the risk factors for recurrence within 90 days in patients with ischemic stroke in China. Method: This was cross-sectional registry-based study in Chinese medicine hospitals from eight provinces and ten cities in China between November 3, 2016 and May 28, 2018. Two thousand one hundred and twenty patients with ischemic stroke aged between 35 and 80 years. Stroke recurrence was defined as an outcome indicator. Computed tomography/magnetic resonance imaging was used as a diagnostic tool for stroke recurrence. Patients' age, sex, height, weight, body mass index (BMI), education level, medical history, family history, smoking, and drinking were recorded. Routine laboratory examinations were performed. Associated factors were investigated by calculating the odds ratio (OR) using logistic regression modeling. Results: In all, 2120 patients were included in the study, 712 (33.6%) of whom were women and 1408 (66.4%) were men, with a mean age of 62.84 +/- 9.35 years. Eighty-two patients experienced stroke recurrence within 90 days, and the accumulative recurrence rates of stroke were 3.9% (95% confidence interval [CI], 3.0%-4.7%). The binary logistic analysis showed that previous history of one (OR = 8.113; 95% CI, 4.497-14.637), two (OR = 8.848; 95% CI, 4.025-9.449), or >= 3 ischemic strokes (OR = 24.599; 95% CI, 9.307-65.018), and BMI <18.5 kg/m2 (OR = 2.842; 95% CI, 1.000-8.075) were independently associated with stroke recurrence within 90 days. Conclusions: The accumulative recurrence rate of ischemic stroke was 3.9% within 90 days. Number of previous history of ischemic stroke and BMI <18.5 kg/m2 were independent risk factors for stroke recurrence. Medical history and solar terms of ischemic stroke were not found to be associated with stroke recurrence within 90 days. Effective secondary prevention for patients with a previous history of ischemic stroke is urgently needed to address this stroke recurrence burden.