Advanced reaction monitoring of pharmaceutical processes enabled with sub/supercritical fluid chromatography

Michael B. Hicks,Weidong Tong, Jason Kowalski, Akasha K. Purohit,Jimmy DaSilva,Erik L. Regalado

The Journal of Supercritical Fluids（2021）

Cited 6|Views24

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Abstract

•SFC-PDA-MS for reaction monitoring of pharmaceutical processes.•Additive-free SFC enables analysis of moisture sensitive reaction mixtures.•Overcoming on-column keto-enol tautomerization and imine hydrolysis via SFC.•SFC outperforms conventional NPLC and CZE methods.•Avoiding tedious pre-column derivatization RPLC-UV procedures with SFC-MS assays.

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Key words

sub/supercritical fluid chromatography,reaction monitoring,pharmaceutical chemistry,method development,additive-free SFC

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