Synthesis of Pterocarpans Through Palladium-Catalyzed Oxyarylation of Alkoxy-2H-chromenes with o-Iodophenols

The oxyarylation of alkoxy-2H-chromenes (1a-e) with o-iodophenols substituted by electron-withdrawing (CHO) and electron-donating (OMe) groups is studied under two experimental conditions: a) Pd(OAc)(2), Ag2CO3 in PEG-400 at 140 degrees C, 10 min and b) oxime-based palladacycle, DIPEA, in PEG-400 at 150 degrees C, 3-4 h. Pterocarpans are obtained in moderate to good chemical yields. (C) 2020 Published by Elsevier Ltd.