Synthesis Of New Pyrrolo[3,4-B]Indol-3-Ones As Latent Substrates For Pyrrolo[3,4-B]Indoles

Mark G. Saulnier, Steven M. Schreiber, Kerri L. Cavanaugh,Robert B. Perni,H. Howard Joyner,and Gordon W. Gribble

ARKIVOC（2021）

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摘要

We report the synthesis of new examples of the 1,4-dihydropyrrolo[3,4-b]indol-3(2H)-one ring system via Fischer indolization between the appropriate phenylhydrazines and pyrrolidine-2,3-diones. Lithiation at the C-1 position with lithium diisopropylamide following by quenching with iodomethane affords 1-methyl-1,4-dihydropyrrolo[3,4-b]indol-3(2H)-ones in excellent yield.[GRAPHICS].

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关键词

Indole, pyrrolo[3,4-b]indole, pyrrolo[3,4-b]indolone, Fischer indolization, pyrroline-2,3-dione

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