Synthesis and characterization of biodegradable polyurethane to assess lysine hydrochloride drug release for further in vivo potentiality and clinical research

Biodegradable polyurethane is considered as a potent biomaterial in various field of biomedical engineering. Polyurethane as a polymer shows their ability to get the product with wide variety of physical and mechanical properties. Biodegradable polyurethane membrane was composed by reacting PEG 400 and HDI in presence of DBTDL, catalyst. Morphological feature and functional group were analyzed by FESEM and FTIR. Degradation, cytotoxicity and in vitro antimicrobial activity were evaluated. In vitro drug release profile was analyzed using lysine hydrochloride drug. The material presented in this study shows the effective release of lysine hydrochloride which may consider as an efficient material for further study and clinical research.