XERODERMA PIGMENTOSUM: A CASE REPORT

Xeroderma pigmentosum is a disorder in the repair of DNA of the skin characterized by the occurrence of pigmented freckles and skin cancer in areas exposed to the sun. A 13-year-old boy from Agrestina, Brazil, had xeroderma pigmentosum for 7 years. The lesions of the face were treated with surgery. The last of these was also treated with radiotherapy (20 sessions). Early in 2011, he underwent removal of a basal cell carcinoma (BCC) concomitantly with radiation therapy, and the condition progressed with aggressive tumor growth. Chemotherapy (docetaxel [Taxotere (Sanofi-Aventis)] and cisplatin) was then associated. Chemotherapy was fractionated in 3 cycles with tumor cytoreduction. The tumor was removed. Histopathologic examination revealed a well-differentiated squamous cell keratinizing, ulcerated with base and free margin. In 2017, he presented a new lower eyelid injury, which made rehabilitation impossible because of the risk of osteoradionecrosis and bone limitation.