Two Cu(II)-based coordination polymers: Magnetic properties and preventative effect on periodontitis via inhibiting plaque formation

Two coordination polymers (CPs) based on Cu(II) of {[Cu(L)]·(CH3CN)}n (1) and {[Cu2(L)2(H2O)] 3H2O}n (2) (H2L = 5-(benzimidazole-1-yl)isophthalic acid) were prepared through the hydrothermal method and then characterized by elemental analysis and single-crystal X-ray diffraction. In addition, the magnetic performances of the complex 1 and the complex 2 were investigated, which revealed antiferromagnet interactions between the centers of the magnet. The preventative effect of the compounds on periodontitis was assessed, and the detailed mechanism was investigated. First, the inhibition of compound 1 or compound 2 against dental plaque formation was evaluated. Afterward, real-time RT-PCR was implemented to detect the expression of p53 and nf-κb in periodontal mucosal cells.