Endogenous sulfur dioxide is a novel inhibitor of hypoxia-induced mast cell degranulation
Journal of Advanced Research（2021）
Abstract
Endogenous sulfur dioxide is a novel inhibitor of hypoxia-induced mast cell degranulation. Endogenous SO2/AAT pathway exists in MCs. Mast cell-derived SO2 upregulates cAMP level through activation of AC and inhibition of PDE, thereby suppressing degranulation of MCs.
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Key words
Endogenous sulfur dioxide,Mast cells,Stabilization,Degranulation,cAMP
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