Stannous Chloride As A Low Toxicity And Extremely Cheap Catalyst For Regio-/Site-Selective Acylation With Unusually Broad Substrate Scope
GREEN CHEMISTRY(2020)
Abstract
This work reports stannous chloride (SnCl2)-catalyzed regio-/site-selective acylation with unusually broad substrate scope. In addition to 1,2- and 1,3-diols and glycosides containingcis-vicinal diol, the substrate scope also includes glycosides withoutcis-vicinal diol. For such a substrate scope, usually, only methods using stoichiometric amounts of organotin reagents can lead to the same protection pattern with high selectivities and highly isolated yields (84-97% in most cases). Therefore, SnCl2, as a low toxicity and extremely cheap reagent, should be the best catalyst for regio-/site-selective acylation compared with any previously reported reagents.
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Key words
Heterogeneous Catalysts
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