Slow Cytomegalovirus-Specific Cd4(+) And Cd8(+) T-Cell Differentiation: 10-Year Follow-Up Of Primary Infection In A Small Number Of Immunocompetent Hosts

Differentiation of human cytomegalovirus specific T cells is a slow process requiring years. In the acute phase, EM predominate; subsequently, no contraction occurs (memory inflation) and TEMRA increase, especially among CD8+ T cells, while few LTM T cells appear. After some years, LTM stabilizes and predominate among CD4+ .