Long-Chain Non-Coding Rna H19-Mir-152-3p Axis Regulates Afp Expression In Hepatocellular Carcinoma

Background: Serum alpha-fetoprotein (AFP) is the most widely used serological marker used to diagnose hepatocellular carcinoma (HCC). High expression of AFP is significantly associated with early postoperative recurrence and poor prognosis. However, the upstream regulation mechanism of AFP expression is not fully understood, and the role of long-chain non-coding RNA (lncRNA) in AFP expression regulation has not been reported. Methods: HCC cases from The Cancer Genome Atlas (TCGA) database were divided into 3 groups: (1) AFP Results: In the 3 groups, 32 lncRNAs were differentially expressed (P 0, P 0, P 0.60, 769 pairs of miRNA-lncRNA interaction were recognized. These predicted lncRNAs were then intersected with the 6 cytoplasm-located lncRNAs. H19 satisfied the constraints, and therefore, a lncRNA H19-miR-152-3p-AFP ceRNA was proposed. Conclusions: Our study revealed that the proposed H19-miR-152-3p-AFP pathway affects the expression of AFP in HCC, suggesting that the H19-miR-152-3p axis may play an important role in the development of typical AFP-positive HCC. Citation Format: Yang Ke, Xiang Kui, Hang Jiang, Tiangen Wu, Cheng Zhang, Jian Zhou, Jinze Li, Heng Zhang, Yueqiang Song, Juan Zhao, Huafeng Duan, Lin Wang, Yan Wang. Long-chain non-coding RNA H19-miR-152-3p axis regulates AFP expression in hepatocellular carcinoma [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3715.