Towards A New Paradigm In Bladder Pain Syndrome And Interstitial Cystitis

Hunner lesion disease, termed 'interstitial cystitis" since the description of Guy Hunner's "elusive ulcer" a century ago, referred to a specific disease with specific findings on endoscopy associated with a typical symptom complex. Unfortunately, there were many patients with a similar symptom presentation who did not meet this restricted definition. Some would have infection, some would have overactive bladder, some would suffer from effects of pelvic radiation, and many would have no known etiology or findings on evaluation other than the symptoms alone.