Copper-Molybdenum Sulfide/Reduced Graphene Oxide Hybrid With Three-Dimensional Wrinkles And Pores For Enhanced Amperometric Detection Of Glucose

A new transitional metal sulfide-reduced graphene oxide hybrid CuxS-MoS2-rGO was developed for enhanced electrocatalytic oxidation and amperometric sensing of glucose. The hybrid was prepared by a facile one-pot hydrothermal approach. The component and structure of the hybrid were characterized by SEM, EDS, XPS, XRD, and Raman spectrum. The MoS2-rGO forms a three-dimensional (3D) wrinkled porous matrix, and element Cu in the form of CuxS (x = 1 or 2) is well dispersed in it. The introduction of Cu greatly elevates the catalysis, while MoS2 plays a key role in forming 3D wrinkled and porous structure, while rGO obviously accelerates the electron transfer. Due to their synergy effect, the hybrid CuxS-MoS2-rGO displays significantly enhanced catalysis towards glucose oxidation (40-fold enhanced oxidation current compared with that of MoS2 or MoS2-rGO or nearly 40% increase than that of CuxS-rGO). Based on this, a nonenzymatic amperometric sensor for glucose was developed, which shows a wide linear range of 2-6330 mu M, a low detection limit of 0.6 mu M, a high stability and adequate selectivity. For glucose sensing in human serum, the developed sensor shows recoveries between 97.2% and 101.2%. Such facile and high-yield approach can be used to prepare other multi-transitional metal sulfide hybrid with promising application in electrochemical sensor and electrocatalysis.