Buruli Ulcer and HIV Coinfection: Cases in Togo
World journal of AIDS(2020)
Abstract
Background: In Togo, as in all sub-Saharan countries, the burden of HIV infection remains high.The registration of new cases of Buruli ulcer every year also remains a major public health problem.Buruli ulcer (BU) is a disabling disease and the presentation of lesions is frequently severe.A feature of BU and HIV coinfection is the rarity of cases, which makes its study difficult, but, nevertheless, important to study its seroprevalence, biological data, risk factors and genetic diversity.The purpose of this study is to explore the comorbidity of Buruli ulcer and HIV by evaluating HIV seroprevalence in BU patients, assessing demographic data, reviewing biological data including CD4+ T cell count, hemoglobin levels, and viral loads, and evaluating clinical and therapeutic data.Methods: This is a cross-sectional study including only BU patients confirmed by Ziehl Neelsen staining and IS 2404 PCR.The patients were hospitalized in the National Reference Center for Tsevie.They were recovered patients and patients undergoing outpatient treatment in the Gati and Tchekpo Deve treatment centers, respectively, within the Sanitary Districts of Zio and Yoto of the Maritime Region during the period from August 2015 to March 2017.Results: The number of HIV-positive BU patients is 4 out of a total of 83 BU patients.All patients are HIV-1 positive.HIV prevalence among BU patients is 4.8% compared to 2.5% nationally and 3% at regional level.Three BU patients are seropositive out of a total of 46 female patients while one patient under 15 years is seropositive out of a total of 37 male BU patients.There are a greater proportion of female patients with BU/HIV coinfections.Half of the BU/HIV positive patients (BU/HIV+) have a CD4+ TL of fewer than 500 cells/μl and the difference is significant between those of the BU HIV-and those of the BU/HIV+ patients.Two patients have unde-How to cite this paper:
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