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Ezh1/2, Swi/Snf, And Mll2 Dependent Heterochromatin Formation And Abnormal Transcriptome In Hematological Malignancies

Makoto Yamagishi,Dai Fujikawa,Makoto Hori,Daisuke Honma,Nobuaki Adachi,Seiichiro Kobayashi,Masako Iwanaga,Atae Utsunomiya,Seiji Okada,Kunihiro Tsukasaki,Kensei Tobinai,Kazushi Araki,Toshiki Watanabe,Kaoru Uchimaru

BLOOD（2017）

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Abstract
The neomorphic alteration of H3K27me3 patterning is a fundamental trait of cancers. We have developed a new clinical strategy; dual inhibition of EZH1 and EZH2 significantly reprogrammed the abnormal epigenome and restored the transcriptome in lymphomas (Blood, 2016; 58th ASH, 2016; NCT02732275).
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mll2 dependent heterochromatin formation,abnormal transcriptome
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