Late-onset Cases of Korsakoff Amnestic Syndrome with CNS Comorbidities: Suggestions for Long-term Management

Goal: The goal of this study was to alert clinicians to Korsakoff syndrome associated with comorbid neurological and neuropsychiatric conditions in patients aged 50 years and older. Methods: The study consists of 4 Korsakoff longitudinal case reports (mean age at onset=60.5 y), supplemented by relevant published reports. Findings: The findings include demographic characteristics, comorbid central nervous system conditions, and interventions. Conclusion: In older patients with Korsakoff syndrome and comorbid central nervous system conditions, the optimal functional outcome depends upon a neurophysiological understanding of all comorbidities plus treatment interventions that can alleviate >1 comorbid condition insofar as feasible.